News Updates Wednesday 14th Nov 2018 :
  • Welcome to INPRESSCO, world's leading publishers, We have served more than 10000+ authors
  • Articles are invited in engineering, science, technology, management, industrial engg, biotechnology etc.
  • Paper submission last date of Nov/Dec 2018 extended to 10 Nov 2018, Submit online or at editor.ijcet@inpressco.com
  • Our journals are indexed in NAAS, University of Regensburg Germany, Google Scholar, Cross Ref etc.
  • DOI is given to all articles

Radiomodulatory Effects of different Phytochemicals on the Irradiated Mouse Model System


Author : Jyoti Verma and Rahul Sharma

Pages : 28-38, DOI: https://doi.org/10.14741/ijcsb/v.7.4
Download PDF
Abstract

The present study was conducted to evaluate the radio-protective effect of three phytochemicals: emodin, acemannan and naringenin on the irradiated splenocytes, bone marrow and liver cells of mouse model system. γ- Radiation induces cellular and DNA damage which was studied by micronucleus assay and karyotypic study was done by metaphase arrest of chromosomes. The radio-protective efficacy of emodin was studied by cell viability assay, comet assay and plasmid relaxation assay. Acemannan showed to possess radio-protective potential when it elevated the levels of SOD and catalase anti-oxidant enzymes in the irradiated liver cells and improved cell proliferation in the irradiated splenocytes. The radio-protective effect of naringenin on the irradiated spleen cells and bone marrow cells was also studied via MTT assay and immunocytochemistry. All three studied phytochemicals were of natural origin and showed to exhibit good radio-protective properties, thereby providing an insight for improving defense mechanism of mouse model system against radiation exposure.

Keywords: Splenocytes, bone marrow, liver cell homogenate, emodin, acemannan, naringenin

Call for Papers
  1. IJCET- Nov/Dec 2018 Issue

    Submission Last Date
    15 Nov
  2. DOI is given to all articles
  3. Current Issue
  4. IJTT-Dec-2018
  5. IJAIE-Dec-2018
  6. IJCSB-Dec-2018
  • Inpressco Google Scholar
  • Inpressco Science Central
  • Inpressco Global impact factor
  • Inpressco aap

International Press corporation is licensed under a Creative Commons Attribution-Non Commercial NoDerivs 3.0 Unported License
©2010-2018 INPRESSCO® All Rights Reserved