Author : Sarmad Tailb Najim, EKhlas A. Salman and Wlada Alamery

This study involved the optimization of determining parameters in reaction conditions of N-phenyl-3-methyl-
3hydroxy-5-pyrozolone process Characterizations were carried out by analyzing the spectrum of Fourier transform
infrared (FTIR), ( nuclear magnetic resonance) 1H NMR, and 13C-NMR.The optimized reaction conditions were
determined by the method has been successfully applied to the assay in pure and pharmaceutical forms in the system,the time taken for a complete reaction, the temperature used for the reaction to occur and the ratio of methyl iodide and phenyl hydrazine unit to ethyl acetoacetate in the final yield of the product. The optimized reaction conditions of 72% yield and 97.8% assay of NPMHP, reaction time of 14 h, reaction temperature of 18°C, These optimization factors allowed good yields of NPMHP providing plenty of opportunities for its multi-applications.

Keywords: Pyrazole, phenyl-3-methyl-3hydroxy-5-pyrozolone, Reaction Conditions for pyrazoles

Article published in International Journal of Current Engineering and Technology, Vol.6, No.2 (April-2016)