Author : Ashutosh Mangotra, Ekta Singhmar , Rajesh Kumar , Anil Khuttan and Sanjeev Kumar Gautam

Cancer as we know that the uncontrolled growth of a cell, is now a day very common and a bigger problem to combat worldwide, accounting for 8.2 million deaths in 2012 according to WHO. Cancer is a generic term for a large group of diseases that can affect any part of the body. The main cause for this deadly disease is found to be in the heart of DNA. The principal targets of genetic alterations may be the four classes of normal regulatory genes-the growth-promoting proto-oncogene, growth-inhibiting tumor suppressor genes, genes that regulate programmed cell death(apoptosis), and genes involved in DNA repair. Now a days, the genetic code seems to be the progressive path to reach our target to cure this disease. Alternatively, the alkaloids of herbs may be the suitable solution. Which treatment is used depends upon the type, location and grade of the cancer as well as the person’s health and wishes. As our understanding about the molecular pathways regulating cancer signatures has embossed an equally strong desire to abolish cancer before the resistance, or relapse that continue to worsen survival data of the disease.

Keywords: Cancer, Genes, Genetic code, Alkaloids and pathways.