Author : Narjis Hadi Al-Saadi, Moayed Kadum Al-Naqib, Zahraa Hassan Ali

Colon cancer is still one of the leading causes of cancer death worldwide and the second most common cause of mortality from cancer. It is linked to numerous reasons such as socioeconomic status, the dramatic change in dietary habits, the presence of refrigeration, chemical preservatives, and the environmental changes. Our study involved the estimation of Ceruloplasmin activity (Cp), copper and zinc levels in patient with colon cancer. Serum samples were collected from 50 patient with colon cancer from Al-Hussain hospital / Kerbala , digestive and liver disease education hospital medical city in Bagdad/ Iraq and teaching oncology hospital Bagdad medical city/Iraq .The results showed decrease in the Cp activity but not significant in patients with colon cancer comparing with the control, whereas Cu concentration was significant increase (p< 0.0001) in patients so there was significant decrease (p< 0.0001) in Zn concentration in patients with colon cancer compared with the control group. Also the patients were divided into four groups according to the stage of cancer, the results revealed no any significant differences (p > 0.05) between the stages in the concentrations of parameters under study except there was significant differences (p<0.05) in concentration of copper when comparing stage 3 versus stage 4. The aim of this study is to find the relation between ceruloplasmin and related elements in patients with colon cancer.

Keywords: colon cancer, ceruloplasmin, copper, zinc.

Article published in International Journal of Current  Engineering  and Technology, Vol.4,No.3 (June- 2014)